MEK4 (MAP2K4) Mouse Monoclonal Antibody [Clone ID: 2D10D8]

CAT#: AM06144SU-N

MEK4 (MAP2K4) mouse monoclonal antibody, clone 2D10D8, Ascites

Product Images

Immunohistochemical analysis of paraffin-embedded human thymoma tissue (left) and spleen tissue (right), showing cytoplasmic localization using MAP2K4 antibody Cat.-No AM06144SU-N with DAB staining.

Specifications

Product Data

• Clone Name: 2D10D8
• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1/10000.
  Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgM
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of MAP2K4 expressed in E. Coli.
• Formulation: State: Ascites
  State: Ascitic fluid
  Preservative: 0.03% Sodium Azide
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
  
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 6416 Human
• Background: MAP2K4 (mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases.MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.
• Synonyms: JNK-activating kinase 1, MAP Kinase Kinase 4, SAPK/ERK kinase 1, PRKMK4, SERK1, MEK-4, MAPKK4, MKK4