DDR2 Mouse Monoclonal Antibody [Clone ID: 3B11E4]

CAT#: AM06186SU-N

DDR2 mouse monoclonal antibody, clone 3B11E4, Ascites

Product Images

Western blot analysis using DDR2 antibody Cat.-No AM06186SU-N against truncated DDR2 recombinant protein.

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  Immunohistochemical analysis of paraffin-embedded human skeletal musle tissues using DDR2 antibody Cat.-No AM06186SU-N

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  Immunohistochemical analysis of paraffin-embedded human skeletal musle tissues using DDR2 antibody Cat.-No AM06186SU-N

Specifications

Product Data

• Clone Name: 3B11E4
• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA: 1/10000.
  Western Bloting: 1/500-1/2000.
  Immunofluorescence: 1/200-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/200-1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of Human DDR2 expressed in E. Coli.
• Specificity: Recognizes Human DDR2. Other species not tested.
• Formulation: State: Ascites
  State: Ascitic fluid
  Preservative: 0.03% Sodium Azide
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Database Link:
  Entrez Gene 4921 Human
• Background: DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.
• Synonyms: NTRKR3, TKT, TYRO10