ROR1 Mouse Monoclonal Antibody [Clone ID: 2H6]

CAT#: AM06399SU-N

ROR1 mouse monoclonal antibody, clone 2H6, Ascites

Product Images

Western blot analysis using ROR1 antibody Cat.-No AM06399SU-N against extracellular domain of human ROR1 (aa30-423).

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  Confocal Immunofluorescence analysis of HEK293 cells trasfected with extracellular ROR1 (aa30-406)-hIgGFc using ROR1 antibody Cat.-No AM06399SU-N (green). Blue: DRAQ5 fluorescent DNA dye.

Specifications

Product Data

• Clone Name: 2H6
• Applications: ELISA, IF, WB
• Recommended Dilution: ELISA: 1/10000.
  Western Blot: 1/500-1/2000.
  Immunofluorescence: 1/200-1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells
• Specificity: Recognizes Human ROR1.
  Other species not tested.
• Formulation: State: Ascites
  State: Ascitic fluid
  Preservative: 0.03% Sodium Azide
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 101 kDa
• Database Link:
  Entrez Gene 4919 Human
• Background: ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases.
• Synonyms: NTRKR1