Fibrillin 1 (FBN1) Mouse Monoclonal Antibody [Clone ID: 11C1.3]

CAT#: AM08022BT-N

Fibrillin 1 (FBN1) mouse monoclonal antibody, clone 11C1.3, Biotin


USD 550.00

3 Days*

Size
    • 200 ug

Product Images

Specifications

Product Data
Clone Name 11C1.3
Applications EM, IF, IHC, WB
Recommended Dilution Immunohistochemistry: 1/50-1/100 (30-60 min at RT). (See Ref.2)
Immunofluorescence. (See Ref.2)
Western Blotting: < / = 1 µg/ml.
Electron microscopic Immunolocalization.
Reactivities Bovine, Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Microfibrils from zonular apparatus of bovine eye.
Specificity This antibody recognises Fibrillin (Mr 350 kDa).
Formulation PBS containing 0.09% Sodium Azide as preservative.
Label: Biotin
State: Liquid purified Ig fraction.
Concentration lot specific
Conjugation Biotin
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name fibrillin 1
Background The fibrillins are extracellular matrix glycoproteins which occur as a major component of a subset of connective tissue microfibrils. These microfibrils have a beaded appearance and a cross-sectional diameter of 10-12 nm. In elastic tissues, these structures are thought to provide the scaffold onto which elastin is assembled to form elastic fibers, although their function in non-elastic tissues is unclear.(Ref.1) In Immunohistochemical staining of paraformaldehyde-fixed human skin, mAb 11C1.3 labels the elastic framework and more specifically the oxytalantic network close to the epidermis. The antibody also exhibits discrete staining of normal fibroblasts in culture and of extracellular (elastin) fibrils in a variety of tissues.(Ref.2,3) There is an aberrant expression of fibrillin in Marfan syndrome.(Ref.4)
Synonyms FBN1, FBN
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.