Cd3e Rat Monoclonal Antibody [Clone ID: C363.29B (YCD3-1)]
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Specifications
Product Data | |
Clone Name | C363.29B (YCD3-1) |
Applications | FC |
Recommended Dilution | Flow Cytometry: Identification and enumeration of CD3+ (< / = 1 µg/10e6 cells). (Ref.1,2). |
Reactivities | Mouse |
Host | Rat |
Isotype | IgG2b |
Clonality | Monoclonal |
Specificity | This antibody is specific to CD3e (Mr. 25 kD). |
Formulation | PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent. Label: APC State: Liquid purified Ig fraction. Label: Allophycocyanin |
Concentration | 0.1 mg/ml |
Conjugation | APC |
Database Link | |
Background | CD3e, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chain ranging in size from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR). It is expressed on all T cells of all mouse strains. (Ref.1,2) CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. The monoclonal antibody C363.29B recognizes an epitope on the 25kD epsilon chain of the CD3/TCR complex. (Ref.1) In the presence of Fc receptor-bearing accessory cells, soluble C363.29B can activate primed and naïve T cell in vitro. Immobilized C363.29 monoclonal antibody can also activate both normal T lymphocytes and cloned T cell lines provided the appropriate accessory signals are present. (Ref.1,3,4) The monoclonal antibody is cytolytic, easily used for cell surface staining and a good immunoprecipitating antibody. (Ref.1) |
Synonyms | T3/Leu-4 |
Reference Data |
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