Cd19 Mouse Monoclonal Antibody [Clone ID: MB19-1]

CAT#: AM08032BT-N

Cd19 mouse monoclonal antibody, clone MB19-1, Biotin


USD 350.00

3 Days*

Size
    • 500 ug

Product Images

Specifications

Product Data
Clone Name MB19-1
Applications FC, IP
Recommended Dilution Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.1-3)
Immunoprecipitation. (Ref.1)
Reactivities Mouse
Host Mouse
Isotype IgA
Clonality Monoclonal
Specificity This antibody is specific to CD19 B cell differentiation antigen (Mr. 95 kDa).
Formulation PBS containing Sodium Azide as preservative.
Label: Biotin
State: Liquid purified Ig fraction.
Concentration 0.5 mg/ml
Conjugation Biotin
Background CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e., B220+/CD43+/HSA+) through fully differentiated B cell stages. (Ref.1-7) Terminally differentiated plasma cells do not express CD19.1 In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation. (Ref.3,4) All splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages are CD19+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. (Ref.1,7) Recent studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow. (Ref.7)
Synonyms Leu-12, B-cell marker
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.