Cd22 Rat Monoclonal Antibody [Clone ID: 2D6]

CAT#: AM08033AC-N

Cd22 rat monoclonal antibody, clone 2D6, APC


USD 350.00

3 Days*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 2D6
Applications FC
Recommended Dilution Flow Cytometry: < / = 0.2 µg/10e6 cells. (Ref.2)
Reactivities Mouse
Host Rat
Isotype IgG1
Clonality Monoclonal
Specificity This antibody is specific to CD22 (Mr 150 kDa), a B Lymphocyte Adhesion Molecule.
Formulation PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent.
Label: APC
State: Liquid purified Ig fraction.
Label: Allophycocyanin
Concentration 0.1 mg/ml
Conjugation APC
Background CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. (Ref.1,2) CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. (Ref.2-4) Its intracellular domain is phosphorylated after antigen receptor crosslinking and is involved in negative regulation of B-cell activation. (Ref.6-9)
Synonyms SIGLEC2, Siglec-2, B-cell receptor CD22, Leu-14, BL-CAM
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.