Cd24a Rat Monoclonal Antibody [Clone ID: 91]
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Specifications
Product Data | |
Clone Name | 91 |
Applications | FC |
Recommended Dilution | Flow Cytometry: < / = 0.3 µg/10e6 cells. (Ref.8) |
Reactivities | Mouse |
Host | Rat |
Isotype | IgG2a |
Clonality | Monoclonal |
Specificity | This antibody is specific to Heat Stable Antigen HSA (Mr 35-45 kDa). |
Formulation | PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent. Label: PE State: Liquid purified Ig fraction. Label: R-Phycoerythrin |
Concentration | 0.1 mg/ml |
Conjugation | PE |
Database Link | |
Background | CD24, also known as heat stable antigen, is a phosphatidylinositol-linked cell surface glycoprotein that is expressed at all stages of B cell development and on most thymocytes. (Ref.1-3) The absence of expression from mature T cells is closely associated with their maturation from CD4+CD8+CD24+ thymocytes to either CD4+CD8-CD24- or CD4-CD8+CD24- T cells. CD24 is also present on mouse granulocytes, monocytes, Langerhans cells and erythrocytes. (Ref.4-6) Its ligand is P-selectin (CD62P). (Ref.7) CD24 may play a role in regulation of B cell proliferation and differentiation, and it has been proposed that heat stable antigen promotes homotypic adhesion between B lymphocytes. (Ref.1-3). The monoclonal antibody 91 can be used to inhibit B-cell differentiation. (Ref.8) |
Synonyms | X62 heat stable antigen, HSA |
Reference Data |
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