Cd38 Rat Monoclonal Antibody [Clone ID: NIMR-5]

CAT#: AM08041PU-N

Cd38 rat monoclonal antibody, clone NIMR-5, Purified

Specifications

Product Data

• Clone Name: NIMR-5
• Applications: FC, FN, IHC, IP
• Recommended Dilution: Flow Cytometry (Ref.1-8).
  Immunoprecipitation (Ref.1).
  Immunohistochemistry on Frozen Sections (Ref.7).
  Functional Assay: Induction of B lymphocyte proliferation (Ref.3-8).
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: BCL1 plasma membrane glycoproteins
• Specificity: This antibody is specific to CD38 (Mr. 42-46 kDa).
  Monoclonal antibodies to CD38 have been shown to induce B- and T-cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis. (Ref.1-8)
• Formulation: 100 mM Borate Buffered Saline, pH 8.2.
  No preservatives or amine-containing buffer salts added.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: 0.5 mg/ml
• Database Link:
  Entrez Gene 12494 Mouse
• Background: Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing Nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells, and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRalphabeta+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages.
• Synonyms: cADPr hydrolase 1, T10