Cd38 Rat Monoclonal Antibody [Clone ID: NIMR-5]
Product Images
Specifications
Product Data | |
Clone Name | NIMR-5 |
Applications | FC, FN, IHC, IP |
Recommended Dilution | Flow Cytometry (Ref.1-8). Immunoprecipitation (Ref.1). Immunohistochemistry on Frozen Sections (Ref.7). Functional Assay: Induction of B lymphocyte proliferation (Ref.3-8). |
Reactivities | Mouse |
Host | Rat |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | BCL1 plasma membrane glycoproteins |
Specificity | This antibody is specific to CD38 (Mr. 42-46 kDa). Monoclonal antibodies to CD38 have been shown to induce B- and T-cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis. (Ref.1-8) |
Formulation | 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction. |
Concentration | 0.5 mg/ml |
Database Link | |
Background | Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing Nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells, and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRalphabeta+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages. |
Synonyms | cADPr hydrolase 1, T10 |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.