Cd40lg Hamster Monoclonal Antibody [Clone ID: MR1]

CAT#: AM08043PU-N

Cd40lg hamster monoclonal antibody, clone MR1, Purified

Specifications

Product Data

• Clone Name: MR1
• Applications: FC, FN, IP
• Recommended Dilution: Flow Cytometry. (Ref.1,5)
  Immunoprecipitation. (Ref.1)
  Functional Assay: In vivo and in vitro blockage of CD154 function. (Ref.1,3,5)
• Reactivities: Mouse
• Host: Hamster
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Activated mouse Th1 clone D1.6 (Ref.1)
• Specificity: This antibody is specific to CD154 (CD40 ligand/gp39), Mr 39-kDa.
  The MR1 monoclonal antibody binds to murine CD154 with high affinity, blocks binding to CD40, and blocks CD154 function. (Ref.1,5)
  Administration of this antibody to mice blocks the ability to mount primary and secondary immune responses to TD antigens, yet does not alter the immune response to TI antigens. (Ref.4)
• Formulation: 100 mM Borate Buffered Saline, pH 8.2.
  No preservatives or amine-containing buffer salts added.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: 0.5 mg/ml
• Gene Name: CD40 ligand
• Database Link:
  Entrez Gene 21947 Mouse
• Background: CD154, formerly known as CD40 ligand and gp39, is a type II integral membrane protein and a member of the tumor necrosis factor (TNF) family of ligands. (Ref.1-7)
  It is an important accessory molecule in T cell-B cell costimulatory interactions, and is expressed predominantly on activated CD4+ T lymphocytes. It is also present on the surface of activated Th0, Th1, and Th2 T cell clones. Its expression is transient and cyclosporinsensitive. (Ref.6)
• Synonyms: CD40 ligand, CD40-L, CD40LG, TNFSF5, TRAP, GP39