CD45 / LCA (CD45RB) Rat Monoclonal Antibody [Clone ID: C363.16A]

CAT#: AM08045BT-N

CD45 / LCA (CD45RB) rat monoclonal antibody, clone C363.16A, Biotin


USD 380.00

3 Days*

Size
    • 500 ug

Product Images

Specifications

Product Data
Clone Name C363.16A
Applications FC
Recommended Dilution Flow Cytometry. < / = 1 µg/10e6 cells. (Ref.1-3)
Reactivities Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Immunogen Cloned mouse Th2 cell lines. (Ref.1)
Specificity This antibody is specific to an exon B-dependent epitope of CD45 glycoprotein.
Formulation PBS containing 0.09% Sodium Azide as preservative.
Label: Biotin
State: Liquid purified Ig fraction.
Concentration 0.5 mg/ml
Conjugation Biotin
Background CD45RB is an isoform of CD45 with exon 5 splicing (encodes B determinant). It is a 220 kD glycoprotein expressed on peripheral B cells, naïve T cells, thymocytes, weakly on macrophages, and dendritic cells. It plays a critical role in TCR and BCR signaling. As T cells become activated and progress from naïve to memory cells, CD45RB expression is downregulated. Additionally, functionally distinct CD4 T cell subsets, which secrete differing cytokine profiles, can be separated by CD45RB intensity. The primary ligands for CD45 are galectin-1, CD2, CD3, CD4 and Thy-1.
Distribution: Peripheral B cells, naïve T cells, most thymocytes, low density on macrophages and dendritic cells.
Function: Phosphatase, T cell development and activation Structure: Phosphatase receptor (CD45 gene exon 5), 220 kD
Synonyms PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.