CD49e / ITGA5 Rat Monoclonal Antibody [Clone ID: 5H10-27]

CAT#: AM08047FC-N

CD49e / ITGA5 rat monoclonal antibody, clone 5H10-27, FITC


USD 430.00

3 Days*

Size
    • 500 ug

Product Images

Specifications

Product Data
Clone Name 5H10-27
Applications FC
Recommended Dilution Flow Cytometry:. < / = 1 µg/10e6 cells. (Ref.1)
Reactivities Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Immunogen C57BL/6 x A/J F1 mouse mast cell line MC/9. (Ref.1)
Specificity This antibody is specific to alpha-5 subunit of the integrin alpha-5 beta-1 Fibronectin Receptor.
It reacts with the alpha-5 chain (VLA-5) of the CD49e/CD29 heterodimeric Fibronectin Receptor. (Ref.1-5)
Formulation PBS containing 0.09% Sodium Azide as preservative.
Label: FITC
State: Liquid purified Ig fraction.
Label: Fluorescein Isothiocyanate Isomer 1
Concentration 0.5 mg/ml
Conjugation FITC
Background Integrin alpha 5 belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell surface mediated signalling. It is expressed on thymocytes, activated T cells, mast cells, and a variety of mouse cell lines.
Soluble 5H10-27 antibody inhibits VLA-5-mediated functions in vitro. (Ref.1,2-4,6) Immobilized 5H10-27 has also been demonstrated to co-stimulate the proliferative response of CD8+ T cells to plate-bound anti-CD3 monoclonal antibody. (Ref.3)
Synonyms Integrin alpha-5, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, VLA5, FNRA
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.