Tfrc Rat Monoclonal Antibody [Clone ID: RI7217]

CAT#: AM08050FC-N

Tfrc rat monoclonal antibody, clone RI7217, FITC


USD 390.00

3 Days*

Size
    • 500 ug

Product Images

Specifications

Product Data
Clone Name RI7217
Applications FC
Recommended Dilution Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.1-3,5)
Reactivities Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Specificity This antibody recognises CD71/Transferrin Receptor, Mr 180-190 kDa (90-95 kDa under reducing conditions).
Formulation PBS containing 0.09% Sodium Azide as preservative.
Label: FITC
State: Liquid purified Ig fraction.
Label: Fluorescein Isothiocyanate Isomer 1
Concentration 0.5 mg/ml
Conjugation FITC
Background CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the Transferrin Receptor. It is essential for the growth of normal and neoplastic cells. (Ref.1,4) It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation. (Ref.4) Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major ironcarrying protein. It may also be involved in signal transduction via its association with the T cell receptor zeta chain.
Clone RI7217 inhibits cell proliferation in vitro. (Ref.2)
Synonyms TfR1, p90, Transferrin receptor protein 1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.