Cd80 Rat Monoclonal Antibody [Clone ID: 1G10]

CAT#: AM08052BT-N

Cd80 rat monoclonal antibody, clone 1G10, Biotin


USD 350.00

3 Days*

Size
    • 500 ug

Product Images

Specifications

Product Data
Clone Name 1G10
Applications FC
Recommended Dilution Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.2,7)
Reactivities Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Specificity This antibody recognises CD80/B7-1 (Mr. 45-47 kDa)
Formulation PBS containing 0.09% Sodium Azide as preservative.
Label: Biotin
State: Liquid purified Ig fraction.
Concentration 0.5 mg/ml
Conjugation Biotin
Background CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL-4, and surface Ig receptor cross linking with peak expression occurring between 48 and 72 hours postactivation. (Ref.1-4)
The interaction of CD80/B7-1 with its ligands, CD28 and CD152/CTLA-4, provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex. (Ref.5,6). This Monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80, but it does not block stimulation of T cells by natural antigenpresenting cells. (Ref.2,7).
Synonyms CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.