Cd86 Rat Monoclonal Antibody [Clone ID: GL1]

CAT#: AM08053PU-N

Cd86 rat monoclonal antibody, clone GL1, Purified


USD 310.00

3 Days*

Size
    • 500 ug

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Specifications

Product Data
Clone Name GL1
Applications FC, FN, IHC, IP
Recommended Dilution Flow Cytometry. (Ref.1-7)
Immunoprecipitation. (Ref.1)
Immunohistochemistry Frozen Sections. (Ref.6)
Functional Assays: In vivo and In vitro blocking assays. (Ref.1,3,5)
Reactivities Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Immunogen LPS-activated mouse B cells.(Ref.1)
Specificity This antibody recognises CD86, the B7-2 co-stimulatory molecule and a ligand for CD28 and CD152/CTLA-4.
The monoclonal antibody GL1 blocks mixed lymphocyte reactions and stimulation of T cells by antigen-presenting cells. (Ref.1,3,5)
Formulation 100 mM Borate Buffered Saline, pH 8.2.
No preservatives or amine-containing buffer salts added.
State: Purified
State: Liquid purified Ig fraction.
Concentration 0.5 mg/ml
Gene Name Mus musculus CD86 antigen (Cd86)
Background CD86 (also known as B7-2) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. (Ref.1-5) CD86 expression is rapidly upregulated by B-cell specific stimuli with peak expression at 18-42 hours after stimulation. (Ref.1,5) CD86, along with CD80/B7-1, is an important accessory molecule in T cell costimulation via its interaction with CD28 and CD152/CTLA-4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. (Ref.1-9).
Synonyms CD28LG2, Activation B7-2 antigen, B70, BU63, B7.2, FUN-1
Reference Data

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