T Cell Receptor (TCR) gamma/delta Hamster Monoclonal Antibody [Clone ID: UC7-13D5]

CAT#: AM08059LE-N

T Cell Receptor (TCR) gamma/delta hamster monoclonal antibody, clone UC7-13D5, Low Endotoxin

Specifications

Product Data

• Clone Name: UC7-13D5
• Applications: FC, FN, IHC, IP
• Recommended Dilution: Flow Cytometry. (Ref.4-7)
  Immunoprecipitation. (Ref.5)
  Immunohistochemistry on Frozen Sections. (Ref.8)
  In vitro Activation of gamma-delta TCR-bearing cells. (Ref.5)
  In vivo Depletion of gamma-delta TCR-expressing T cells. (Ref.5)
• Reactivities: Mouse
• Host: Hamster
• Isotype: IgG
• Clonality: Monoclonal
• Specificity: This Monoclonal antibody is specific to the gamma-delta heterodimer and plate-bound UC7-13D5 activates gamma-delta TCR-bearing cells. (Ref.4-7)
  It does not react with alpha-beta TCR-expressing T cells.
• Formulation: PBS containing no preservatives.
  State: Low Endotoxin
  State: Liquid purified Ig fraction.
• Concentration: 0.5 mg/ml
• Background: T cell receptors (TCR) recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level.
  The TCR gamma/delta heterodimer of the CD3/T-cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. (Ref.1) It is expressed during thymopoiesis and on the small subpopulation of gamma/delta TCR expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are gamma/delta+ and have limited receptor diversity. (Ref.1,2) The TCR gamma/delta heterodimer recognizes peptide antigen bound to MHC antigens, and subsequent signal transduction mediated by the invariant chains leads to T cell activation. (Ref.3)
• Synonyms: TCRG, TCRD, T-Cell Receptor gamma, T-Cell Receptor delta, T-Cell Receptor gamma delta