Ctla4 Hamster Monoclonal Antibody [Clone ID: 9H10]

CAT#: AM08061PU-N

Ctla4 hamster monoclonal antibody, clone 9H10, Purified


USD 310.00

In Stock*

Size
    • 500 ug

Product Images

Specifications

Product Data
Clone Name 9H10
Applications FC, FN, IP
Recommended Dilution Flow Cytometry: < / = 3 µg/10e6 cells. Suggest use of these reagents is in a final volume 100µl.
Immunoprecipitation.
In vitro and in vivo blocking of CTLA-4 action by soluble antibody.
Promotion of in vitro CTLA-4 signalling by cross-linked antibody.
See Ref.1 for more details.
Reactivities Mouse
Host Hamster
Isotype IgG
Clonality Monoclonal
Immunogen Heat-killed Staphylococcus A bacteria coated with mouse CTLA-4/human IgG1 fusion protein. (Ref.1)
Specificity This Monoclonal antibody is specific to CD152/CTLA-4 costimulatory receptor (Mr 33-37 kDa).
Formulation 100 mM Borate Buffered Saline, pH 8.2.
No preservatives or amine-containing buffer salts added.
State: Purified
State: Liquid purified Ig fraction.
Concentration 0.5 mg/ml
Background CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. (Ref.1,2) Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80/B7-1 and CD86/B7-2) on antigen-presenting cells. (Ref.3) CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T-cell stimulation via the T cell receptor (TCR) complex. (Ref.1,3,4) Whereas CD28 provides a positive costimulatory signal, CD152/CTLA-4 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signalling through the TCR through its association with tyrosine phosphatases such as SHP-2. (Ref.1,5,6)
Synonyms CTLA-4
Reference Data

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