CD45 / LCA (CD45RC) Rat Monoclonal Antibody [Clone ID: C455.1F]

CAT#: AM08070PU-N

CD45 / LCA (CD45RC) rat monoclonal antibody, clone C455.1F, Purified

Specifications

Product Data

• Clone Name: C455.1F
• Applications: FC, IP
• Recommended Dilution: Flow Cytometry: Identification and enumeration of CD45RC+ cells.
  Immunoprecipitation.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: This antibody recognises an exon C-dependent epitope of CD45 glycoprotein.
• Formulation: 100 mM Borate Buffered Saline, pH 8.2.
  No preservatives or amine-containing buffer salts added.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: 0.5 mg/ml
• Background: The CD45 family of cell surface glycoprotein antigens exist as a set of isoforms. (Ref.1-4) The patterns of monoclonal antibody recognition of the CD45 phenotypes can be restricted (CD45RA, RB and RC), or broader, such as the CD45 T 200 species (See also products AM08044). (Ref.1-4)The "restricted" subsets of this group arise as a result of translation of alternatively spliced mRNAs from exons A, B and C (exons 4, 5 and 6), where exons 3-15 encode the extracellular domain of the CD45 molecule. The restricted epitopes are differentially expressed on T and B lymphocytes, including functionally distinct T cells. CD45 (LCA) is a transmembrane phosphotyrosine phosphatase expressed on leucocytes. Myeloid cells do not express the RC isoform.
• Synonyms: PTPRC, Leukocyte common antigen, L-CA, T200