CD81 / TAPA1 Hamster Monoclonal Antibody [Clone ID: 2F7]

CAT#: AM08071PU-N

CD81 / TAPA1 hamster monoclonal antibody, clone 2F7, Purified

Specifications

Product Data

• Clone Name: 2F7
• Applications: FC, FN, IHC, IP
• Recommended Dilution: Flow Cytometry: Identification and enumeration of CD81+ cells.
  Immunoprecipitation.
  Immunohistochemistry on Frozen Sections.
  In vitro blocking of thymocyte interactions with CD81.
  See Ref.2 for more details.
• Reactivities: Mouse
• Host: Hamster
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Mouse epithelial cell line PAM212.
• Specificity: This antibody recognises Mouse CD81 (Mr 25 kDa), a member of the transmembrane 4 integral membrane protein
  family. This antibody can block thymocyte interaction with CD81 in vitro. (Ref.2)
• Formulation: 100 mM Borate Buffered Saline, pH 8.2.
  No preservatives or amine-containing buffer salts added.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: 0.5 mg/ml
• Background: TAPA1, or CD81, is a member of the transmembrane 4 superfamily, also known as the Tetraspanin family. Most of these members are cell surface proteins that are characterised by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TAPA1 is a cell surface glycoprotein that is known to complex with integrins. It appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. TAPA1 gene is localized in the tumor suppressor gene region and thus it is a candidate gene for malignancies.