MHC Class II I-Ab Rat Monoclonal Antibody [Clone ID: NIMR-4]
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Specifications
Product Data | |
Clone Name | NIMR-4 |
Applications | FC, FN |
Recommended Dilution | Flow Cytometry: < / = 1 µg/10e6 cells. Complement-dependent Cytotoxicity Assays. |
Reactivities | Mouse |
Host | Rat |
Isotype | IgG2b |
Clonality | Monoclonal |
Specificity | Specific to MHC Class II molecules. This antibody reacts specifically with a non-polymorphic I-A-encoded epitope on MHC Class II antigens. Class II antigens are predominantly expressed on antigen-presenting cells including B lymphocytes, macrophages, dendritic cells and certain epithelial cells. |
Formulation | 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction. |
Concentration | 0.5 mg/ml |
Background | MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma. |
Synonyms | H2-Eb1, H-2 class II histocompatibility antigen I-A beta chain |
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