CD8A Mouse Monoclonal Antibody [Clone ID: 76-2-11]

CAT#: AM08107PU-N

CD8A mouse monoclonal antibody, clone 76-2-11, Purified


USD 490.00

3 Days*

Size
    • 500 ug

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Specifications

Product Data
Clone Name 76-2-11
Applications CT, FC, IHC, IP
Recommended Dilution
Flow Cytometry – Quality tested 1,11-15,17-28
Immunohistochemistry-Frozen Sections – Reported in literature 2-6,16
Immunohistochemistry-Paraffin Sections – Reported in literature 7
Immunoprecipitation – Reported in literature 1
Blocking – Reported in literature 8,9
Depletion – Reported in literature 10
Complement Mediated Cell Depletion – Reported in literature 1
Reactivities Porcine
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Fresh dd miniature swine thymocytes
Specificity This antibody reacts with Porcine CD8 alpha (Mr. 32-34 kDa). (Ref-1-3)
Formulation 100 mM Borate Buffered Saline, pH 8.2.
No preservatives or amine-containing buffer salts added.
State: Purified
State: Liquid purified Ig fraction.
Concentration 0.5 mg/ml
Background The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 is expressed on most thymocytes and approximately 1/3 of peripheral blood T cells in humans. CD8 alpha/beta heterodimers are expressed only on TCR alpha/beta T cells, whereas CD8 alpha homodimers can be expressed on alpha/beta and gamma/delta T cells and some NK cells in humans. The pattern of expression in other species has not been well documented.
Synonyms CD8 alpha chain, CD8A, MAL
Reference Data

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