KIT Mouse Monoclonal Antibody [Clone ID: kit2c75]

CAT#: AM08136FC-N

KIT mouse monoclonal antibody, clone kit2c75, FITC

Specifications

Product Data

• Clone Name: kit2c75
• Applications: FC
• Recommended Dilution: Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.6-10)
• Reactivities: Chicken
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Sp2/0 cells, Sp/chkit4A4, transfected with Chicken c-kit cDNA.
• Specificity: This antibody recognizes Chicken c-Kit.
• Formulation: PBS containing 0.09% Sodium Azide as preservative.
  Label: FITC
  State: Liquid purified Ig fraction.
  Label: Fluorescein Isothiocyanate Isomer 1
• Concentration: 0.5 mg/ml
• Conjugation: FITC
• Gene Name: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
• Database Link:
  Entrez Gene 378783 Chicken
• Background: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.
• Synonyms: SCFR, KIT