CD8A Mouse Monoclonal Antibody [Clone ID: RFT-8]
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Other products for "CD8A"
Specifications
Product Data | |
Clone Name | RFT-8 |
Applications | FC, IHC |
Recommended Dilution | Flow Cytometry: < / = 1 µg/10e6 cells. Immunohistochemistry on Frozen Sections. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Specificity | This antibody recognizes CD8. |
Formulation | 100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction. |
Concentration | lot specific |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens CD8a molecule (CD8A), transcript variant 1 |
Database Link | |
Background | The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8 functions primarily as a coreceptor with MHC Class I-restricted TCR's in antigen recognition. (Ref.1-2) |
Synonyms | CD8 alpha chain, CD8A, MAL |
Reference Data | |
Protein Families | Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane |
Protein Pathways | Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway |
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