CD16 (FCGR3A) Mouse Monoclonal Antibody [Clone ID: GRM1]

CAT#: AM08159PU-N

CD16 (FCGR3A) mouse monoclonal antibody, clone GRM1, Purified

Specifications

Product Data

• Clone Name: GRM1
• Applications: FC, IHC, IP, WB
• Recommended Dilution: Flow Cytometry: < / = 1 µg/10e6 cells.
  Immunohistochemistry on Frozen Sections.
  Western Blotting (Non-reducing conditions).
  Immunoprecipitation.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: This antibody recognizes CD16/FcgammaRIII.
• Formulation: 100 mM Borate Buffered Saline, pH 8.2.
  No preservatives or amine-containing buffer salts added.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens Fc fragment of IgG receptor IIIa (FCGR3A), transcript variant 3
• Database Link:
  Entrez Gene 2214 Human
• Background: CD16 (FcgammaRIII) serves as a low affinity IgG receptor. Human CD16 is expressed in two forms CD16a and CD16b. CD16a is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. CD16b is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.
  CD16 is involved in NK activation and signal transduction. (Ref.1-5)
• Synonyms: FCGR3A, CD16A, FCG3, FCGR3, IGFR3, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2

Reference Data

• Protein Families: ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
• Protein Pathways: Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity, Systemic lupus erythematosus