LAMP1 Mouse Monoclonal Antibody [Clone ID: H4A3]

CAT#: AM08169FC-N

LAMP1 mouse monoclonal antibody, clone H4A3, FITC


USD 310.00

3 Days*

Size
    • 100 Tests

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Specifications

Product Data
Clone Name H4A3
Applications FC
Recommended Dilution Flow Cytometry: 10 µL/10e6 cells.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Specificity This antibody recognizes CD107a/LAMP-1.
Formulation PBS containing 0.09% Sodium Azide as preservative.
Label: FITC
State: Liquid purified Ig fraction.
Label: Fluorescein Isothiocyanate Isomer 1
Conjugation FITC
Storage Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium. (Ref.1-7)
Synonyms LAMP-1, LAMPA, LGP120
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.