Bcl-2-like 1 (Bcl-xL) Mouse Monoclonal Antibody [Clone ID: 7B2.5]
CAT#: AM08172BT-N
Bcl-2-like 1 (Bcl-xL) mouse monoclonal antibody, clone 7B2.5, Biotin
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Specifications
Product Data | |
Clone Name | 7B2.5 |
Applications | FC |
Recommended Dilution | Flow Cytometry: < / = 3 µg/10e6 cells. |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG3 |
Clonality | Monoclonal |
Immunogen | Recombinant Bcl-xS. |
Specificity | This antibody recognizes Bcl-xL. |
Formulation | PBS containing 0.09% Sodium Azide as preservative. Label: Biotin State: Liquid purified Ig fraction. |
Concentration | 0.1 mg/ml |
Conjugation | Biotin |
Background | Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. (Ref.1) It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. (Ref.2) Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis (Ref.3,4) while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. (Ref.5-8) Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. (Ref.9-13) In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2. (Ref.5,14) Other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity. (Ref.15,16) |
Synonyms | Bcl2-L-1, BCL2L1, BCL2L, BCLX, Bcl-x, bcl-xL, bcl-xS, Bcl-2-like protein 1 |
Reference Data |
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