FADD Mouse Monoclonal Antibody [Clone ID: 1A11]

CAT#: AM08189SE-N

FADD mouse monoclonal antibody, clone 1A11, Sepharose


USD 520.00

3 Days*

Size
    • 50 Tests

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Specifications

Product Data
Clone Name 1A11
Applications ELISA, IP, WB
Recommended Dilution ELISA.
Immunoprecipitation.
Western Blot.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Specificity This antibody is specific for FADD.
Formulation 2 ml of 100 mM Borate buffered saline, pH 8.2.
No preservatives or amine-containing buffer salts added
Label: Sepharose
State: Liquid purified Ig fraction.
Label: 4B (SEPH)
Conjugation Sepharose
Background Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1a-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation. (Ref.1-6)
Synonyms FAS-associated death domain protein, MORT1, GIG3
Note Shake well before use.
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.