TLR2 Mouse Monoclonal Antibody [Clone ID: 2B4A1]

CAT#: AM08191FC-N

TLR2 mouse monoclonal antibody, clone 2B4A1, FITC


USD 370.00

3 Days*

Size
    • 100 Tests

Product Images

Specifications

Product Data
Clone Name 2B4A1
Applications FC
Recommended Dilution Flow Cytometry: 10 µl/10e6.
Reactivities Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Specificity This antibody is specific for Toll-like Receptor 2 (TLR2).
Formulation 1.0 mL of PBS containing 0.09% Sodium Azide as preservative.
Label: FITC
State: Liquid purified Ig fraction.
Label: Fluorescein Isothiocyanate Isomer 1
Conjugation FITC
Storage Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name toll like receptor 2
Background The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. To date, ten mammalian homologs of TLRs have been described. Activation of TLR2 leads to the initiation of apoptosis and the activation of the NK-kB pathway by the adaptor molecule MyD88. TLR2 recognizes and is activated by components from a broad variety of microorganisms including lipoproteins from Gram-negative bacteria, Mycoplasma, spirochetes, peptidoglycan and LTAs from Gram-positive bacteria, lipoarabinomannan from mycobacteria, glycoinositolphospholipids, phenolsoluble modulin, zymosan from yeast and neisserial porins. TLR2 has been reported to functionally associate with TLR1 and TLR6 in order to recognize various lipopeptides. (Ref.1-16)
Synonyms Toll-like receptor 2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.