MMP3 Mouse Monoclonal Antibody [Clone ID: SB14d]

CAT#: AM08199HR-N

MMP3 mouse monoclonal antibody, clone SB14d, HRP

Specifications

Product Data

• Clone Name: SB14d
• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1/1,000-1/4,000.
  Immunohistochemistry (Frozen/Paraffin): 1/1,000-1/2,000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant MMP-3.
• Specificity: This antibody is specific for Human MMP-3.
  Does not cross react to Human MMP-1, MMP-2 or MMP-9.
• Formulation: 50% Glycerol/50% PBS, pH 7.4 without preservatives.
  Label: HRP
  State: Liquid purified Ig fraction.
  Label: Horseradish Peroxidase
• Conjugation: HRP
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 4314 Human
• Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.
  MMP3 is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP3 is reported to be implicated in rheumatoid arthritis and some forms of cancer.
• Synonyms: Stromelysin-1, SL-1, Matrix metalloproteinase-3, Transin-1, MMP3, STMY1