SARM (SARM1) (93-292) Mouse Monoclonal Antibody [Clone ID: Sarmy-1]
CAT#: AM08374PU-N
SARM (SARM1) (93-292) mouse monoclonal antibody, clone Sarmy-1, Purified
Specifications
Product Data | |
Clone Name | Sarmy-1 |
Applications | IHC, IP |
Recommended Dilution | Immunohistochemistry on Paraffin Sections: 10 µg/ml. Immunoprecipitation: 1/200. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Recombinant human SARM (aa 93-292) |
Specificity | This antibody recognizes human SARM. |
Formulation | PBS containing 10% Glycerol and 0.02% Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction |
Concentration | 1 mg/ml |
Database Link | |
Background | Toll-like receptors (TLRs) play an essential role in the detection and elimination of invading microbes. They are type-1 transmembrane receptors, containing extracellular leucine rich repeats and an intracellular Toll/interleukin-1 receptor (TIR) domain. Upon stimulation, these receptors interact with specific TIR domain-containing adaptor proteins. Five such adaptors have been discovered to date, MyD88, Mal (MyD88 adaptor-like)/TIRAP (TIR domain-containing adaptor protein), Trif (TIR-domain-containing adaptor inducing interferon-beta), TRAM (Trif-related adaptor molecule) and SARM (SAM and ARM-containing protein). Different TLRs use different combinations of these adaptors, leading to the activation of common and unique pathways involved in the elimination of the invading microbe. |
Synonyms | SARM, SAMD2, KIAA0524 |
Reference Data |
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