TLR8 (750-850) Mouse Monoclonal Antibody [Clone ID: 44C143]

CAT#: AM08388PU-N

TLR8 (750-850) mouse monoclonal antibody, clone 44C143, Purified

Product Images

Western blot analysis of TLR8 in cell lysates from 293 transfected with human TLR8 using antibody at a concentration of 2 ug/ml.

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  at 5 ug/ml staining TLR8 in formalin fixed and paraffin embedded brain cortex.

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  at 5 ug/ml staining TLR8 in formalin fixed and paraffin embedded spleen tissue.

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  Intracellular flow analysis of TLR8 in 1x10e6 Ramos cells using 0.5 ug of antibody. Shaded histogram represents Ramos cells without antibody, Green represents isotype control, Purple represents anti-TLR8 antibody

Specifications

Product Data

• Clone Name: 44C143
• Applications: FC, IHC, WB
• Recommended Dilution: Flow Cytometry.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1 - 3 µg/ml.
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: A KLH-conjugated synthetic peptide corresponding to a region within amino acids 750-850 of Human TLR8.
• Specificity: The antibody recognizes Toll-like receptor 8 at aa 750-850.
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purification: Protein G Chromatography
• Database Link:
  Entrez Gene 51311 Human
• Background: The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). TLR8 gene contains three exons, two of which have coding function (4). TLR8 cDNA codes for a protein of approximate molecular weight of 120 kDa (4,5).
• Synonyms: Toll-like receptor 8, UNQ249/PRO286