NANOG (1-154) Mouse Monoclonal Antibody [Clone ID: 5A10]
Specifications
Product Data | |
Clone Name | 5A10 |
Applications | ELISA, FC, IHC, WB |
Recommended Dilution | ELISA. Western blot (1/500-1/2,000). Flow Cytometry. Immunohistochemistry on Paraffin Sections (1/50-1/100). |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | Recombinant Human Nanog (1-154 aa) purified from E. coli |
Specificity | The antibody recognizes NANOG. |
Formulation | PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction |
Concentration | 1.0 mg/ml |
Purification | Protein-G affinity chromatography |
Gene Name | Nanog homeobox |
Database Link | |
Background | Nanog is a multidomain homeobox transcription factor that functions to maintain the undifferentiated state of pluripotent stem cells. Nanog expression counteracts the differentiation-promoting signals induced by the extrinsic factors LIF, Stat3 and BMP. When Nanog expression is downregulated, cell differentiation can proceed. Proteins that regulate Nanog expression include transcription factors Oct4, SOX2, FoxD3, and Tcf3 and tumor suppressor p53. |
Synonyms | FLJ12581; FLJ40451; hNanog |
Reference Data |
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