TDP43 (TARDBP) Mouse Monoclonal Antibody [Clone ID: k1B8]
Other products for "TARDBP"
Specifications
Product Data | |
Clone Name | k1B8 |
Applications | ELISA, IHC, WB |
Recommended Dilution | ELISA. Western blot (1/1,000-1/2,000). Flow Cytometry. Immunohistochemistry on Paraffin Sections (1/50-1/100). |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Recombinant Human TARDBP (1-260 aa) purified from E. coli. |
Specificity | The antibody recognizes Human TARDBP. Other species not tested. |
Formulation | PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol State: Purified State: Liquid purified Ig fraction |
Concentration | 1.0 mg/ml |
Purification | Protein-G Affinity Chromatography |
Gene Name | Homo sapiens TAR DNA binding protein (TARDBP) |
Database Link | |
Background | TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene. |
Synonyms | TDP43, TDP-43 |
Reference Data | |
Protein Families | Transcription Factors |
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