HAX1 Mouse Monoclonal Antibody [Clone ID: AT3C5]

CAT#: AM09085PU-N

HAX1 mouse monoclonal antibody, clone AT3C5, Purified

Product Images

Cell lysates of MCF7 (30ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human HAX1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

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  Western blot analysis : Cell lysates of HeLa (30 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human HAX-1 (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Specifications

Product Data

• Clone Name: AT3C5
• Applications: ELISA, WB
• Recommended Dilution: ELISA.
  Western blot (1:1000 - 1:2000).
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Recombinant human HAX1 (1-279 aa) purified from E. coli
• Specificity: The antibody recognizes human HAX-1.
  Other species not tested.
• Formulation: PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Protein-G affinity chromatography
• Gene Name: Homo sapiens HCLS1 associated protein X-1 (HAX1), transcript variant 1
• Database Link:
  Entrez Gene 10456 Human
• Background: HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1 (HS1), one of the substrates of receptor-coupled tyrosine kinases activated during clonal expansion and deletion in lymphoid cells. It also interacts with the product of the polycystic kidney disease 2 (PKD2) gene and with the F-actin-binding protein, cortactin. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease.
• Synonyms: HAX-1, HS1BP1, HCLS1-associated protein X-1, HS1-associating protein X-1, HS1-binding protein 1