EGF Mouse Monoclonal Antibody [Clone ID: S-177]

CAT#: AM09151PU-N

EGF mouse monoclonal antibody, clone S-177, Aff - Purified


USD 540.00

2 Weeks*

Size
    • 500 ug

Product Images

Specifications

Product Data
Clone Name S-177
Applications ELISA
Recommended Dilution ELISA.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Purified recombinant human EGF, 6kDa, 53 amino acid residues
Specificity Reactive with natural and recombinant Human EGF.
Does not cross react with other Human cytokines tested such as IL-1beta, IL-8, MCAF, TGF-beta and SAA
Formulation 0.01M PBS, pH 7.2 without preservatives.
State: Aff - Purified
State: Lyophilized purified Ig fraction.
Reconstitution Method Double distillated water is recommended to adjust the final concentration to 1.00 mg/ml.
Concentration lot specific
Purification Affinity Chromatography on Protein G.
Conjugation Unconjugated
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Gene Name Homo sapiens epidermal growth factor (EGF), transcript variant 1
Background Epidermal growth factor (EGF) has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. EGF exerts its actions by binding to the EGFR, a 170 kDa protein.
Epidermal growth factor (EGF) is a key growth factor regulating cell survival. Through its binding to cell surface receptors, EGF activates an extensive network of signal transduction pathways that include activation of the PI3K/AKT, RAS/ERK and JAK/STAT pathways. Because of its key role in driving the proliferation of cells, EGFR is a target of several anti-cancer drugs currently in development.
Synonyms Urogastrone, Epidermal growth factor, URG, HOMG4
Reference Data
Protein Families Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transmembrane
Protein Pathways Bladder cancer, Cytokine-cytokine receptor interaction, Endocytosis, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.