M-CSF (CSF1) Mouse Monoclonal Antibody [Clone ID: 116]

CAT#: AM09180PU-N

M-CSF (CSF1) mouse monoclonal antibody, clone 116, Purified


USD 540.00

2 Weeks*

Size
    • 500 ug

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Specifications

Product Data
Clone Name 116
Applications ELISA
Recommended Dilution ELISA.
Reactivities Human
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Purified recombinant Human M-CSF (rhM-CSF).
Specificity This monoclonal antibody is specifically reactive to rhM-CSF.
Does not cross react with BSA or other Human cytokines tested such as IL1 beta, IL-8, IL-16, EGF, G-CSFR, GM-CSF, MCP-1, MCP-3, TGF beta and TNF alpha.
Formulation 0.01M PBS, pH 7.2 without preservatives.
State: Purified
State: Lyophilized purified IgG fraction.
Reconstitution Method Restore with Double distillated water to adjust the final concentration to 1.00 mg/ml
Purification Affinity Chromatography on Protein G.
Conjugation Unconjugated
Storage Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens colony stimulating factor 1 (CSF1), transcript variant 1
Background Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte macrophage CSF (GMCSF), granulocyte CSF (GCSF), macrophage CSF (MCSF), and Interleukin-3 (IL-3, Multi CSF). Both GMCSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, GCSF and MCSF are lineage restricted hematopoietic growth factors, stimulating final mitotic divisions and the terminal cellular maturation of the partially differentiated hematopoietic progenitors.
Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF).
Synonyms CSF1, MCSF, Macrophage colony-stimulating factor 1, Macrophage Colony Stimulating Factor
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.