Prostate Specific Antigen (KLK3) (free) Mouse Monoclonal Antibody [Clone ID: 108]

CAT#: AM09251PU-N

Prostate Specific Antigen (KLK3) (free) mouse monoclonal antibody, clone 108, Aff - Purified


USD 485.00

2 Weeks*

Size
    • 500 ug

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Specifications

Product Data
Clone Name 108
Applications ELISA
Recommended Dilution ELISA: This monoclonal PSA antibody can be used as Capture antibody in a Sandwich ELISA for Human free PSA detection in combination with a HRP-conjugated Tracer antibody Cat.-No AM09250HR-N that is derived from PSA mAb clone 103 (Cat.-No AM09250PU-N). 
Suggested Capture Coating Dose: 0.5 µg/well.
Substrate: TMB.
If the above suggested conditions are followed approximately 22 pg/mL of Free PSA can be detected.
Reactivities Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Purified Human Free PSA.
Specificity This monoclonal antibody reacts with Human free PSA, but does not react with complexed PSA.
Formulation 0.01M PBS, pH 7.2
State: Aff - Purified
State: Lyophilized purified Ig fraction
Reconstitution Method Restore with Double distilled water to adjust the final concentration to 1.0 mg/ml.
Purification Affinity Chromatography on Protein G
Conjugation Unconjugated
Storage Upon receipt, store (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens kallikrein related peptidase 3 (KLK3), transcript variant 3
Background Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates two transcript variants encoding different isoforms. Additional transcript variants have been described, but it is unclear if these transcripts are normally expressed or if they are specific to benign or malignant tumors.
Synonyms Prostate-specific antigen, Semenogelase, Gamma-seminoprotein, P-30 antigen
Reference Data
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Pathways in cancer, Prostate cancer

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.