PML Protein (PML) Mouse Monoclonal Antibody [Clone ID: B3E9]

CAT#: AM09254PU-N

PML Protein (PML) mouse monoclonal antibody, clone B3E9, Aff - Purified


USD 485.00

2 Weeks*

Size
    • 500 ug

Product Images

Specifications

Product Data
Clone Name B3E9
Applications WB
Recommended Dilution Western Blot: Use PML antibody at 1/2,000 dilution to differentiate normal PML and Chimeric PML/RAR alpha molecules based on their molecular weight.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant partial Human PML.
Specificity This antibody recognizes normal PML proteins of lower Molecular Weight, and also recognizes the High Molecular Weight PML/RAR-alpha Chimeric protein in promyelocytic leukemia patients.
Formulation 0.01M PBS, pH 7.4 without preservatives.
State: Aff - Purified
State: Lyophilized purified Ig fraction.
Reconstitution Method Restore by adding appropriate volume of distilled water to reach a final antibody concentration of 1.0 mg/ml.
Purification Affinity Chromatography on Protein G.
Conjugation Unconjugated
Storage Store the antibody (in aliquots) at -20°C.
After reconstitution, aliquot and store at -20°C.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens promyelocytic leukemia (PML), transcript variant 6
Background PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals.
Synonyms RING finger protein 71, MYL, TRIM19
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Acute myeloid leukemia, Pathways in cancer, Ubiquitin mediated proteolysis

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.