PML Protein (PML) Mouse Monoclonal Antibody [Clone ID: B4C8]

CAT#: AM09255PU-N

PML Protein (PML) mouse monoclonal antibody, clone B4C8, Aff - Purified


USD 485.00

2 Weeks*

Size
    • 500 ug

Product Images

Specifications

Product Data
Clone Name B4C8
Applications WB
Recommended Dilution EIA.
Western Blot: A106Kd band was observed in K562 cell extract in Western blotting experiment. The K562 cells express the high molecular weight PML/RARa chimera.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant partial human PML
Specificity This antibody recognizes normal PML proteins of lower molecular weight, and also recognizes the high molecular weight PML/RARα chimeric protein in promyelocytic leukemia patients.
Formulation 0.01M PBS, pH 7.4
State: Aff - Purified
State: Lyophilized purified Ig fraction
Reconstitution Method Restore in appropriate volume of distilled H2O to reach a final antibody concentration of 1.0 mg/ml.
Purification Affinity chromatography
Conjugation Unconjugated
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens promyelocytic leukemia (PML), transcript variant 6
Background PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals.
Synonyms RING finger protein 71, MYL, TRIM19
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Acute myeloid leukemia, Pathways in cancer, Ubiquitin mediated proteolysis

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.