ELK1 pSer383 Mouse Monoclonal Antibody [Clone ID: B4A12]

CAT#: AM09315PU-N

ELK1 pSer383 mouse monoclonal antibody, clone B4A12, Aff - Purified


USD 570.00

2 Weeks*

Size
    • 500 ug

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Specifications

Product Data
Clone Name B4A12
Applications ELISA
Recommended Dilution Indirect ELISA: The antibody is reactive to Serine383 phosphorylated Human ELK-1 peptide conjugated with KLH or the peptide- BSA conjugate.
The suggested antigen Coating quantity is 1 µg/ml of peptide/or peptide conjugating in pH 9.5 carbonate buffer, 100 µl/well.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Peptide of a phosphorylated fragment of ELK1 (pSer383) conjugated with KLH.
Specificity Reactive to Serine383 phosphorylated Human ELK-1 peptide fragment conjugated with KLH or the peptide-BSA conjugate.
Not reactive to unconjugated Serine383 phosphorylated Human ELK-1 peptide, KLH or BSA.
Formulation 0.01M PBS, pH 7.0 without preservatives
State: Aff - Purified
State: Lyophilized purified IgG fraction
Reconstitution Method Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification Affinity Chromatography on Protein G
Conjugation Unconjugated
Storage Upon receipt, store (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens ELK1, member of ETS oncogene family (ELK1), transcript variant 1
Background ELK1 belongs to the EST transcription factor family. Proteins in the family have a unique DNA binding domain that binds to conserved DNA sequences. Phosphorylation of ELK1 at Serine 383 and 389 by mitogen-activated protein kinases (MAPKs) activates ELK1. The binding of ELK1 to target sequences is also regulated by its co-factor, serum response factor (SRF), by alternative splicing, and by SUMOylation. ELK1 regulates the transcription of c-fos and genes encoding cytoskeleton proteins, and was found to play a role in longterm memory formation, drug addiction and other neurological disorders.
Synonyms Elk-1
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Endometrial cancer, ErbB signaling pathway, Focal adhesion, GnRH signaling pathway, Insulin signaling pathway, MAPK signaling pathway, Prion diseases

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.