SHP1 (PTPN6) Mouse Monoclonal Antibody [Clone ID: PTY11]

CAT#: AM09319PU-N

SHP1 (PTPN6) mouse monoclonal antibody, clone PTY11, Purified

Specifications

Product Data

• Clone Name: PTY11
• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA.
  Western Blot.
  Immunocytochemistry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant protein corresponding to full-length PTP1-C
• Specificity: This antibody recognizes single 67kDa PTP1-C in Human cells that express the enzyme and the SH2(C) domain.
• Formulation: 0.01M PBS, pH 7.2 without preservatives
  State: Purified
  State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
• Purification: Affinity chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Upon receipt, store (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens protein tyrosine phosphatase, non-receptor type 6 (PTPN6), transcript variant 1
• Database Link:
  Entrez Gene 5777 Human
  UniProt ID P29350
• Background: The phosphorylation state of receptors and signal transduction molecules influences almost every cell activities. The phosphorylation rate is regulated by kinases which add phosphate group and by phosphatases which remove phosphate group form the amino acid residues on protein molecules. Protein tyrosine phosphatase 1 C (PTP1C) is a tyrosine phosphatase highly expressed in heomatopoietic cells. PTP1C was found to co-precipitate with B lymphocytespecific cell surface glycoprotein CD22, after anti-immunoglobulin stimulation. Study with PTP1C deficient mice showed that the phosphatase may implicate with negative selection in B cell immunity.
• Synonyms: PTPN-6, HCP, PTP1C, Protein-tyrosine phosphatase 1C, PTP-1C, SH-PTP1, Protein-tyrosine phosphatase SHP-1

Reference Data

• Protein Families: Druggable Genome, Phosphatase, Stem cell - Pluripotency
• Protein Pathways: Adherens junction, B cell receptor signaling pathway, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway