Aurora B (AURKB) Mouse Monoclonal Antibody [Clone ID: AT2B1]

CAT#: AM09372PU-S

Aurora B (AURKB) mouse monoclonal antibody, clone AT2B1, Purified

Product Images

Immunofluorescence of human HeLa cells stained with Hoechst 3342 (Blue) for chromatin staining and monoclonal anti-human Aurora kinase B antibody. (1:2000) with Texas Red (Red).

Specifications

Product Data

• Clone Name: AT2B1
• Applications: ELISA, FC, IF, WB
• Recommended Dilution: ELISA.
  WesternBlot.
  Flow Cytometry.
  Immunofluorescence: 1/1000-1/2000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Recombinant human Aurora kinase B (1-344aa) purified from E. coli
• Specificity: The antibody recognizes Human Aurora kinase B. Other species not tested.
• Formulation: PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography on Protein G
• Gene Name: Homo sapiens aurora kinase B (AURKB), transcript variant 1
• Database Link:
  Entrez Gene 9212 Human
• Background: The aurora family (A, B and C) are serine threonine kinases and key regulators of chromosome segregation during mitosis. Aurora kinase B is a chromosomal passenger protein that regulates chromosome segregation and cytokinesis. Aurora kinase B is associated with the level of genetic instability within tumours and patient survival. It is strongly expressed in exponentially proliferating bronchial epithelial cells in culture and that this expression is markedly reduced in confluent cells. It is also shown that almost all tumours show higher levels of Aurora kinase B expression than their matched normal lung tissues, which could therefore simply be a consequence of a higher proliferative index, or be typical of the progenitor cell and atypical of the bulk of normal lung cells.
• Synonyms: Aurora-B, Aurora/IPL1-related kinase 2, STK-1, AURKB, AIK2, AIM1, ARK2, STK12

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Stem cell - Pluripotency