NQO2 Mouse Monoclonal Antibody [Clone ID: AT1E3]

CAT#: AM09380PU-S

NQO2 mouse monoclonal antibody, clone AT1E3, Purified


USD 230.00

2 Weeks*

Size
    • 50 ul

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Specifications

Product Data
Clone Name AT1E3
Applications ELISA, WB
Recommended Dilution ELISA.
Western blot (1:250 - 1:500).
Reactivities Human, Mouse
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant human NQO2 (1-231aa) purified from E. coli
Specificity The antibody recognizes human and mouse NQO2. Other species not tested.
Formulation PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Protein-G affinity chromatography
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens NAD(P)H dehydrogenase, quinone 2 (NQO2), transcript variant 3
Background Quinone oxidoreductase (NQO1 and NQO2) are cytosolic proteins that catalyze metabolic redaction of quinines and derivates.NQO2 is inhibited by flavones such as quercetin. Also benzo(a)pyrene is another known inhibitor of NQO2. Even though overlapping substrates specificities have been observed for NQO1 and NQO2, such as for CB1954 activation, significant differences exist in relative affinities for the various substrates.The detoxification role of NQO2 has not been found, and it has no known endogenous biological substrates. However, NQO1 plays an important role in the detoxification of various endogenous and exogenous quinones, including estrogen quinines. Also NQO2 has a melatonin-binding site, which may explain the anti-oxidant role of melatonin related with circadian rhythm.
Synonyms NMOR2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.