PTS

CAT#: AM09382PU-N

Mouse Monoclonal Anti-PTS Antibody, Purified

Product Images

Western blot analysis : Mouse kidney lysates (40ug) and recombinant protein were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PTS (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Specifications

Product Data

• Clone Name: AT2B2
• Applications: WB
• Recommended Dilution: ELISA, WB
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Recombinant human PTS (1-145aa) purified from E. coli
• Specificity: The antibody recognizes human and mouse PTS. Other species not tested.
• Formulation: PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
• Concentration: lot specific
• Purification: Protein-G affinity chromatography
• Storage: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
  Shelf life: one year from despatch.
• Predicted Protein Size: 16.2 kDa
• Gene Name: 6-pyruvoyltetrahydropterin synthase
• Database Link:
  NP_000308
  Entrez Gene 5805 Human
• Background: PTS or PTPS (6-Pyruvoyl tetrahydroprotein synthase) is involved in the biosynthesis of tetahydrobiopterin (BH4), the cofactor of several enzymes such as the nitric oxide synthase and the aromatic amino acid hdroxylases. Inherited deficiency of PTS is the most frequent cause of hyperphenylalninemia (HPA) characterized by depletion of the biogenic amine neutotransmitters, dopamine and serotonin, and is accompanied by severe progressive mental retardation. PTS was showed a homohexameric enzyme composed of a dimer or trimers in the crystallography and several experiments.
• Synonyms: FLJ97081; PTPS

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Folate biosynthesis, Metabolic pathways