CD45 (PTPRC) (CD45RB) Mouse Monoclonal Antibody [Clone ID: 2B11 + PD7/26]

CAT#: AM10066SU-N

CD45 (PTPRC) (CD45RB) mouse monoclonal antibody, clone 2B11 + PD7/26, Supernatant

Product Images

Formalin-Fixed, Paraffin-Embedded Human lymph node stained with CD45 antibody Cat.-No. AM10066SU-N using peroxidase conjugate and DAB chromogen. Note cell membrane staining of B- and T-lymphocytes.

Specifications

Product Data

• Clone Name: 2B11 + PD7/26
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/100-1/200
  Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
  Use Polymer anti Mouse/Rabbit IgG as a detection system.
  Positive Control: Tonsil or lymph node.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: PD7/26/16: Human peripheral blood lymphocytes maintained in T cell growth factor.
  2B11: Isolated neoplastic cells from T cell lymphoma.
• Specificity: Recognizes CD45/RB (LCA).
  Cellular Localization: Cell membrane.
• Formulation: State: Supernatant
  State: Tissue Culture Supernatant
  Stabilizer: 0.2% BSA
  Preservative: 15mM Sodium Azide
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens CD163 molecule (CD163), transcript variant 1
• Database Link:
  Entrez Gene 9332 HumanEntrez Gene 5788 Human
• Background: CD45 leukocyte common antigen (LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portion of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals.
  Antibody to CD45 is useful in differential identification of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
• Synonyms: PTPRC, Leukocyte common antigen, L-CA, T200

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane