CDX2 Rabbit Monoclonal Antibody [Clone ID: EPR2764Y]

CAT#: AM10075SU-N

CDX2 rabbit monoclonal antibody, clone EPR2764Y, Supernatant

Product Images

Formalin-Fixed, Paraffin-Embedded Human colon adenocarcinoma stained with CDX2 antibody using peroxidase conjugate and DAB chromogen. Note the nuclear staining of tumor cells.

Specifications

Product Data

• Clone Name: EPR2764Y
• Applications: IF, IHC, WB
• Recommended Dilution: Western blot.
  Immunocytochemistry.
  Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/200
  Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
  Use Polymer anti Mouse/Rabbit IgG as a detection system.
  Positive Control: Colon.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Synthetic peptide corresponding to residues near the N-terminus of Human CDX2.
• Specificity: Recognizes Human CDX2.
  Cellular Localization: Nuclear.
• Formulation: State: Supernatant
  State: Liquid Tissue Culture Supernatant
  Stabilizer: 0.2% BSA
  Preservative: 15mM Sodium Azide
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens integrin subunit beta 3 (ITGB3)
• Database Link:
  Entrez Gene 3690 HumanEntrez Gene 1045 Human
• Background: CDX2,a member of the caudal-related homeobox family, is an intestine-specific transcription factor that regulates both proliferation and differentiation in intestinal epithelial cells. It plays an important role in triggering cells towards the phenotype of differentiated villus enterocytes as well as in the maintenance of the phenotype. An inverse correlation between the severity of dysplasia and the level of CDX2 expression has been reported. Over 95% of invasive colorectal carcinoma were also demonstrated to be positive for CDX-2 expression. CDX2 protein expression is restricted in both normal and neoplastic intestinal epithelial cells.
• Synonyms: Homeobox protein CDX-2, CDX-3, CDX3

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton