Oct4 (POU5F1) Mouse Monoclonal Antibody [Clone ID: C-10]

CAT#: AM10125SU-N

Oct4 (POU5F1) mouse monoclonal antibody, clone C-10, Purified


USD 515.00

5 Days*

Size
    • 1 ml

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Specifications

Product Data
Clone Name C-10
Applications IHC
Recommended Dilution Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/100
Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
Use Polymer anti Mouse/Rabbit IgG as a detection system.
Positive Control: Seminoma.
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Amino acids 1-134 of Oct-4 of Human origin.
Specificity Oct-3/4 (C-10) is recommended for detection of Oct-3A (Oct-4) and Oct-3B of Mouse, Rat and Human origin by Western Blotting, Immunoprecipitation, Immunofluorescence, and Immunohistochemistry on Paraffin.
Cellular Localization: Nuclear.
Formulation State: Purified
State: Tris-HCl buffer containing stabilizing protein and 0.09 % sodium azide.
Concentration lot specific
Storage Store the antibody undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens neurofilament, light polypeptide (NEFL)
Background Transcription factors containing the POU homeo domain have been shown to be important regulators of tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables them to adopt various monomer configurations on DNA. The versatility of POU protein operation is additionally conferred at the dimerization level. Oct-3 (also known as Oct-4) is a mammalian POU transcription factor expressed by early embryo cells and germ cells. Oct-3/4 is essential for the identity of the pluripotential founder cell population in the mammalian embryo. A critical amount of Oct-3/4 is required to sustain stem-cell self renewal, and up or down regulation induce divergent developmental programmes. Two isoforms of Oct-3, termed Oct-3A and Oct-3B, are generated by alternative splicing. The gene which encodes Oct-3/4 maps to human chromosome 6p21.3.
Synonyms POU5F1, OCT3, OCT4, OTF3, POU domain, class 5, transcription factor 1, Octamer-binding transcription factor 3, Oct-3, Oct-4
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways Amyotrophic lateral sclerosis (ALS)

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.