p57 Kip2 (CDKN1C) Mouse Monoclonal Antibody [Clone ID: KP10]

CAT#: AM10128SU-N

p57 Kip2 (CDKN1C) mouse monoclonal antibody, clone KP10, Supernatant

Product Images

Formalin-Fixed, Paraffin-Embedded Human partial (let) and complete (right) moles stained with p57 antibody Cat.-No. AM10128SU-N using peroxidase conjugate and DAB chromogen. Note the nuclear staining of cytotrophoblasts in partial mole and negative in complete mole.

Specifications

Product Data

• Clone Name: KP10
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/200
  Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
  Use Polymer anti Mouse/Rabbit IgG as a detection system.
  Positive Control: Colon carcinoma or placenta.
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Recombinant Human p57Kip2 protein.
• Specificity: Recognizes p57Kip2.
  Cellular Localization: Nuclear.
• Formulation: State: Supernatant
  State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens neurofilament, light polypeptide (NEFL)
• Database Link:
  Entrez Gene 18039 MouseEntrez Gene 1028 Human
• Background: p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.
• Synonyms: p57KIP2

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS
• Protein Pathways: Amyotrophic lateral sclerosis (ALS)