Perforin (PRF1) Mouse Monoclonal Antibody [Clone ID: MRQ-23]

CAT#: AM10133SU-N

Perforin (PRF1) mouse monoclonal antibody, clone MRQ-23, Supernatant

Product Images

Formalin-Fixed, Paraffin-Embedded Human skin T/NK cell lymphoma stained with Perforin antibody Cat.-No. AM10133SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic granular staining of lymphoma cells.

Specifications

Product Data

• Clone Name: MRQ-23
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/10-1/50
  Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
  Use Polymer anti Mouse/Rabbit IgG as a detection system.
  Positive Control: Spleen.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant protein corresponding to C-terminal region of Human Perforin.
• Specificity: Recognizes Perforin.
  Cellular Localization: Granular cytoplasmic.
• Formulation: Tris HCl
  State: Supernatant
  State: Liquid purified tissue Culture Supernatant
  Preservative: < 0.1% Sodium Azide
• Concentration: lot specific
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens neurofilament, light polypeptide (NEFL)
• Database Link:
  Entrez Gene 4747 HumanEntrez Gene 5551 Human
• Background: Perforin is a potent cytolytic poreforming protein. It is a specific marker of functionally active cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Perforin is a key effector mechanisms in T cell-mediated cytotoxicity. It mediates cytolysis of target cells by membrane damage and apoptosis.
• Synonyms: Perforin-1, Pore forming protein, PFN, PFP, Cytolysin

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS
• Protein Pathways: Amyotrophic lateral sclerosis (ALS)