Cd247 Hamster Monoclonal Antibody [Clone ID: H146-968]

CAT#: AM12004BT-N

Cd247 hamster monoclonal antibody, clone H146-968, Purified


USD 250.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name H146-968
Applications FC, IF
Recommended Dilution This clone (H146-968) has been reported to work in Flow Cytometry (in permeabilized cells), Western Blotting and ELISA.
Reactivities Human, Mouse
Host Hamster
Isotype IgG
Clonality Monoclonal
Immunogen Synthetic peptide KLH conjugated corresponding to amino acids 151-164 of Mouse CD3 zeta
Specificity This antibody detects the zeta chain subunit of the T cell receptor (TCR)(CD247).
Formulation PBS containing 0.02% Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.
State: Purified
State: Liquid purified Ig fraction.
Label: Biotin
Concentration 0.1 mg/ml
Purification Protein G Affinity Chromatography.
Gene Name Mus musculus CD247 antigen (Cd247), transcript variant zeta
Background The TCR complex consists of a ligand specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma, delta, eta and zeta subunits. This complex regulates assembly and expression of the receptor and is thought to be responsible for transmembrane transduction of signals after binding to TCRαβ.
Studies have suggested that the CD3z subunit (also know as CD247) plays an important role in two distinct cellular compartments. In the cytoplasm, it may function to regulate Ag receptor expression and in the plasma membrane it may be required for optimal signaling by the physiologic ligand Ag/MHC. The CD3z subunit is also associated with the CD16 IgG Fc receptor on NK cells.
Synonyms T3Z, TCRZ, CD3 zeta chain
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.